Solubilisation of griseofulvin, quercetin and rutin in micellar formulations of triblock copolymers E62P39E62 and E137S18E137

Maria Elenir N P Ribeiro; Icaro G P Vieira; Igor Marques Cavalcante; Nágila M P S Ricardo; David Attwood; Stephen G Yeates; Colin Booth

doi:10.1016/j.ijpharm.2009.05.047

Solubilisation of griseofulvin, quercetin and rutin in micellar formulations of triblock copolymers E62P39E62 and E137S18E137

Int J Pharm. 2009 Aug 13;378(1-2):211-4. doi: 10.1016/j.ijpharm.2009.05.047. Epub 2009 Jun 6.

Authors

Maria Elenir N P Ribeiro¹, Icaro G P Vieira, Igor Marques Cavalcante, Nágila M P S Ricardo, David Attwood, Stephen G Yeates, Colin Booth

Affiliation

¹ Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 6.021, CEP 60455-760, Fortaleza, Ceará, Brazil.

PMID: 19501147
DOI: 10.1016/j.ijpharm.2009.05.047

Abstract

The solubilisation of two poorly soluble flavonoids, quercetin and rutin, in micellar solutions of mixtures of a block copolymer of ethylene oxide and styrene oxide (E(137)S(18)E(137)) with one of ethylene oxide and propylene oxide (E(62)P(39)E(62)) has been studied at 25 and 37 degrees C. Solubilisation capacities were higher than those for the model poorly water-soluble drug griseofulvin and comparable with published values for the solubilisation of rutin by beta-cyclodextrin.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / administration & dosage
Antioxidants / chemistry
Epoxy Compounds / chemistry
Ethylene Oxide / chemistry
Griseofulvin / administration & dosage
Griseofulvin / chemistry*
Micelles
Polymers / chemistry*
Quercetin / administration & dosage
Quercetin / chemistry*
Rutin / administration & dosage
Rutin / chemistry*
Solubility
Temperature
beta-Cyclodextrins / chemistry

Substances

Antioxidants
Epoxy Compounds
Micelles
Polymers
beta-Cyclodextrins
Griseofulvin
Rutin
Quercetin
styrene oxide
Ethylene Oxide
betadex
propylene oxide