Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4389-93. doi: 10.1016/j.bmcl.2009.05.070. Epub 2009 May 24.

Abstract

Three new phenolic glycosides, salviifosides A-C (13), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-beta-d-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds (1-3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B (2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha).

MeSH terms

  • Alangiaceae / metabolism*
  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Chemistry, Pharmaceutical / methods*
  • Dinoprostone / metabolism*
  • Glycosides / chemistry*
  • Lipopolysaccharides / metabolism*
  • Mice
  • Models, Chemical
  • Nitric Oxide / metabolism*
  • Phenol / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / metabolism*
  • Plants, Medicinal / metabolism*
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Anti-Inflammatory Agents
  • Glycosides
  • Lipopolysaccharides
  • Plant Extracts
  • Tumor Necrosis Factor-alpha
  • Nitric Oxide
  • Phenol
  • Dinoprostone