Molecular determinants of fluoroquinolone antibacterial agents pharmacokinetics

Curr Clin Pharmacol. 2009 Sep;4(3):191-7. doi: 10.2174/157488409789375348. Epub 2009 Sep 1.

Abstract

This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.

Publication types

  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / antagonists & inhibitors
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacokinetics*
  • Biological Transport
  • Biotransformation
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • Fluoroquinolones / adverse effects
  • Fluoroquinolones / pharmacokinetics*
  • Humans
  • Orphan Nuclear Receptors / drug effects
  • Orphan Nuclear Receptors / metabolism
  • Polymorphism, Genetic

Substances

  • ATP-Binding Cassette Transporters
  • Anti-Bacterial Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Fluoroquinolones
  • Orphan Nuclear Receptors
  • Cytochrome P-450 Enzyme System