Abstract
This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
MeSH terms
-
ATP-Binding Cassette Transporters / antagonists & inhibitors
-
ATP-Binding Cassette Transporters / genetics
-
ATP-Binding Cassette Transporters / metabolism
-
Anti-Bacterial Agents / adverse effects
-
Anti-Bacterial Agents / pharmacokinetics*
-
Biological Transport
-
Biotransformation
-
Cytochrome P-450 Enzyme Inhibitors
-
Cytochrome P-450 Enzyme System / genetics
-
Cytochrome P-450 Enzyme System / metabolism
-
Drug Interactions
-
Fluoroquinolones / adverse effects
-
Fluoroquinolones / pharmacokinetics*
-
Humans
-
Orphan Nuclear Receptors / drug effects
-
Orphan Nuclear Receptors / metabolism
-
Polymorphism, Genetic
Substances
-
ATP-Binding Cassette Transporters
-
Anti-Bacterial Agents
-
Cytochrome P-450 Enzyme Inhibitors
-
Fluoroquinolones
-
Orphan Nuclear Receptors
-
Cytochrome P-450 Enzyme System