A simple method for fabricating selective injection microstructured optical fibers (MOFs) using a conventional fusion splicer is described. The effects of fusion current, fusion duration and offset position on the hole collapse property of the MOFs are investigated. With this method, the central hollow-core and the holes in the cladding region can be selectively infiltrated, which allows for the fabrication of novel hybrid polymer-silica and liquid-silica MOFs for various applications.