The prevalence of macrovascular disease (MVD) was examined in 206 diabetics (115 women and 91 men) and 105 controls (59 women and 46 men). The diagnosis of MVD was established on the basis of responses to the standard questionnaires and Minnesota codes for the ECG. The prevalence of MVD was for 2.2 times higher in diabetics than in nondiabetics (p less than 0.001). Angina pectoris was for 3.1 times more frequently found in diabetics (p less than 0.001), possible myocardial infarction for 4.5 (p less than 0.01) and vascular disease of the lower extremities for 3.1 times (p less than 0.05). The analysis by sex showed that the prevalence of MVD in diabetics and nondiabetics was statistically significant for women only.