84 patients who were wounded in Armenian earthquake (1988) have been examined. It was marked that all the purulent wounds of soft tissues of the extremities had been infected by bacterial associations. The most of them were resistant to penicillinum, tetracyclinum, laevomycetinum, kanamycinum, kefzol, keflin, and highly sensible to mezlocilinum, cyprofloksacinum, cefaperazonum and ceftazidimium. The article formulates the organization and methodical principles, determines a diagnostic algorithm for clinico-microbiological examination of patients with purulent wounds.