Quantitative 35Cl nuclear quadrupole resonance in tablets of the antidiabetic medicine Diabinese

Anal Chem. 2009 Jul 1;81(13):5574-6. doi: 10.1021/ac900656e.

Abstract

Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within +/-3%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chlorine / chemistry
  • Chlorpropamide / chemistry*
  • Hypoglycemic Agents / chemistry*
  • Isotope Labeling
  • Magnetic Resonance Spectroscopy / methods*
  • Radio Waves
  • Tablets

Substances

  • Hypoglycemic Agents
  • Tablets
  • Chlorine
  • Chlorpropamide