Historically, the health care needs of poor men and men of color have been neglected in the United States, resulting in significant disparities in health and health outcomes. Dedicated resources to address the particular needs of men are necessary to eliminate the health disparities that afflict underserved men. The following article compiles and shares some of the lessons learned as experienced by three Community Voices sites that have been active in men's health. Community Voices Miami's Overtown Men's Health Study, Denver Health Men's Health Initiative, and Baltimore Men's Health Center are working to address the health needs of men in some of the most vulnerable communities in the United States. Examples of community-specific assessment of men's needs, community engagement, service delivery, service to special populations, marketing, addressing sustainability, and advances in public policy to improve men's health are presented.