Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk-3-en-2-ones

Abdolmajid Riahi; Martina Wurster; Michael Lalk; Ulrike Lindequist; Peter Langer

doi:10.1016/j.bmc.2009.05.023

Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk-3-en-2-ones

Bioorg Med Chem. 2009 Jul 1;17(13):4323-6. doi: 10.1016/j.bmc.2009.05.023. Epub 2009 May 15.

Authors

Abdolmajid Riahi¹, Martina Wurster, Michael Lalk, Ulrike Lindequist, Peter Langer

Affiliation

¹ Institut für Chemie, Universität Rostock, Rostock, Germany.

PMID: 19481948
DOI: 10.1016/j.bmc.2009.05.023

Abstract

4-Hydroxy-4-(pyridyl)alk-3-en-2-ones were prepared by base-mediated condensation of ketones with pyridinecarboxylates. Several derivatives show weak antimicrobial activity against Gram-positive and Gram-negative bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Bacillus subtilis / drug effects*
Bacillus subtilis / growth & development
Escherichia coli / drug effects*
Escherichia coli / growth & development
Ketones / chemical synthesis
Ketones / chemistry
Ketones / pharmacology*
Pyridines / chemical synthesis*
Pyridines / chemistry
Pyridines / pharmacology*
Staphylococcus aureus / drug effects*
Staphylococcus aureus / growth & development

Substances

Anti-Bacterial Agents
Ketones
Pyridines
pyridine