Abstract
A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and mass-spectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O(*-)(2)) production by human neutrophils with IC(50) values of 18.7+/-4.4 and 17.0+/-6.8 microM, resp.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzofurans / chemistry*
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Benzofurans / isolation & purification
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Benzofurans / pharmacology
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Free Radical Scavengers / chemistry*
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / pharmacology
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Humans
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Neutrophils / drug effects
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Neutrophils / metabolism*
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Plant Stems / chemistry
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Rosaceae / chemistry*
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Superoxides / metabolism*
Substances
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4-methoxydibenzo(b,d)furan-2,3-diol
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Benzofurans
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Free Radical Scavengers
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Superoxides
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dibenzofuran