A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils

Chem Biodivers. 2009 May;6(5):774-8. doi: 10.1002/cbdv.200800118.

Abstract

A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and mass-spectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O(*-)(2)) production by human neutrophils with IC(50) values of 18.7+/-4.4 and 17.0+/-6.8 microM, resp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry*
  • Benzofurans / isolation & purification
  • Benzofurans / pharmacology
  • Free Radical Scavengers / chemistry*
  • Free Radical Scavengers / isolation & purification
  • Free Radical Scavengers / pharmacology
  • Humans
  • Neutrophils / drug effects
  • Neutrophils / metabolism*
  • Plant Stems / chemistry
  • Rosaceae / chemistry*
  • Superoxides / metabolism*

Substances

  • 4-methoxydibenzo(b,d)furan-2,3-diol
  • Benzofurans
  • Free Radical Scavengers
  • Superoxides
  • dibenzofuran