Fast and easy access to efficient bifunctional chelators for MRI applications

Giuseppe Gugliotta; Mauro Botta; Giovanni Battista Giovenzana; Lorenzo Tei

doi:10.1016/j.bmcl.2009.05.024

Fast and easy access to efficient bifunctional chelators for MRI applications

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3442-4. doi: 10.1016/j.bmcl.2009.05.024. Epub 2009 May 10.

Authors

Giuseppe Gugliotta¹, Mauro Botta, Giovanni Battista Giovenzana, Lorenzo Tei

Affiliation

¹ Dipartimento di Scienze dell'Ambiente e della Vita, Università degli Studi del Piemonte Orientale A. Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy.

PMID: 19477128
DOI: 10.1016/j.bmcl.2009.05.024

Abstract

Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd(III) complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Azepines / chemical synthesis
Azepines / chemistry*
Chelating Agents / chemical synthesis
Chelating Agents / chemistry*
Contrast Media / chemical synthesis*
Contrast Media / chemistry
Gadolinium / chemistry
Magnetic Resonance Imaging*

Substances

6-amino-6-methylperhydro-1,4-diazepine
Azepines
Chelating Agents
Contrast Media
Gadolinium