A graphene platform for sensing biomolecules

Angew Chem Int Ed Engl. 2009;48(26):4785-7. doi: 10.1002/anie.200901479.

Abstract

Sensitive platform: The use of graphene oxide (GO) as a platform for the sensitive and selective detection of DNA and proteins is presented. The interaction of GO and dye-labeled single-stranded DNA leads to quenching of the dye fluorescence. Conversely, the presence of a target DNA or protein leads to the binding of the dye-labeled DNA and target, releasing the DNA from GO, thereby restoring the dye fluorescence (see picture).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • Biosensing Techniques / methods*
  • Carbon / chemistry*
  • DNA, Single-Stranded / analysis
  • DNA, Single-Stranded / chemistry
  • Fluorescent Dyes / chemistry
  • Proteins / chemistry
  • Spectrometry, Fluorescence

Substances

  • Aptamers, Nucleotide
  • DNA, Single-Stranded
  • Fluorescent Dyes
  • Proteins
  • Carbon