The most common extraintestinal manifestations of Crohn's disease concern joints, skin, and eyes; however other organs such as liver, pancreas, kidneys, heart, lungs or brain can also be affected. Aseptic abscesses are an emergent entity in patients with inflammatory bowel disease and despite medical treatment the surgical approach may represent an alternative therapy. We report a case of a young woman with splenic aseptic abscesses as complication of Crohn's disease. After steroid sparing and antibiotic failure the patient underwent successful splenectomy.