Abstract
We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism
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Administration, Oral
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Amnesia / chemically induced
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Amnesia / drug therapy*
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Amnesia / enzymology
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Amnesia / psychology
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Animals
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Avoidance Learning / drug effects
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Behavior, Animal / drug effects*
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Cholinesterase Inhibitors / administration & dosage
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology*
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Cognition / drug effects*
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Cornus / chemistry*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Fruit
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Hippocampus / drug effects
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Hippocampus / enzymology
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Iridoids / administration & dosage
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Iridoids / isolation & purification
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Iridoids / pharmacology*
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Male
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Memory, Short-Term / drug effects
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Mice
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Mice, Inbred ICR
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Nootropic Agents / administration & dosage
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Nootropic Agents / isolation & purification
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Nootropic Agents / pharmacology*
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Scopolamine
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Time Factors
Substances
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Cholinesterase Inhibitors
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Iridoids
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Nootropic Agents
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Scopolamine
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Acetylcholinesterase
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loganin