Abstract
A novel ABC transporter gene, vga(C), was identified on the 14,365-bp multiresistance plasmid pKKS825 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The vga(C) gene encodes a 523-amino-acid protein which confers resistance not only to streptogramin A antibiotics but also to lincosamides and pleuromutilins. Plasmid pKKS825 also carries the resistance genes aadD, tet(L), and dfrK, which may enable the coselection of vga(C) under selective pressure by kanamycin/neomycin, tetracyclines, and trimethoprim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / genetics*
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Animals
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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Diterpenes / pharmacology
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Drug Resistance, Multiple, Bacterial / genetics*
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Kanamycin / pharmacology
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Lincosamides / pharmacology
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Methicillin-Resistant Staphylococcus aureus* / drug effects
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Methicillin-Resistant Staphylococcus aureus* / genetics
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Molecular Sequence Data
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Neomycin / pharmacology
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Plasmids / genetics*
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Pleuromutilins
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Polycyclic Compounds
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Staphylococcal Infections / microbiology*
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Streptogramin A / pharmacology
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Swine
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Swine Diseases / microbiology*
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Tetracyclines / pharmacology
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Trimethoprim / pharmacology
Substances
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ATP-Binding Cassette Transporters
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Anti-Bacterial Agents
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Bacterial Proteins
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Diterpenes
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Lincosamides
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Polycyclic Compounds
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Tetracyclines
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VgA protein, Staphylococcus aureus
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Kanamycin
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Streptogramin A
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Trimethoprim
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Neomycin