Synthesis of 3,6-branched arabinogalactan-type tetra- and hexasaccharides for characterization of monoclonal antibodies

Anikó Fekete; Anikó Borbás; Sándor Antus; András Lipták

doi:10.1016/j.carres.2009.04.025

Synthesis of 3,6-branched arabinogalactan-type tetra- and hexasaccharides for characterization of monoclonal antibodies

Carbohydr Res. 2009 Aug 17;344(12):1434-41. doi: 10.1016/j.carres.2009.04.025. Epub 2009 May 4.

Authors

Anikó Fekete¹, Anikó Borbás, Sándor Antus, András Lipták

Affiliation

¹ Research Group for Carbohydrates of the Hungarian Academy of Sciences, H-4010, Debrecen, PO Box 94, Hungary.

PMID: 19467537
DOI: 10.1016/j.carres.2009.04.025

Abstract

Synthesis of tetra- and hexasaccharides built up from a beta-(1-->6)-linked galactopyranosyl backbone with arabinofuranosyl side chains at position 3 and with a 3-aminopropyl spacer related to arabinogalactans is described. These oligosaccharides were prepared for investigation of monoclonal antibodies raised against arabinogalactan proteins (AGPs) from pressed juice of Echinacea purpurea.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal / immunology*
Carbohydrate Sequence
Echinacea / immunology*
Echinacea / metabolism*
Galactans / chemistry
Galactans / immunology*
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Molecular Structure
Oligosaccharides / chemical synthesis*
Oligosaccharides / chemistry
Oligosaccharides / immunology*

Substances

Antibodies, Monoclonal
Galactans
Oligosaccharides
arabinogalactan