Blood compatibility improvement of titanium oxide film modified by doping La(2)O(3)

J Mater Sci Mater Med. 2009 Oct;20(10):2019-23. doi: 10.1007/s10856-009-3784-3. Epub 2009 May 24.

Abstract

La(2)O(3) doped titanium oxide (TiO(2)) films with different concentration were deposited by means of the Radio-Frequency magnetron sputtering technique. The microstructure and surface properties of TiO(2) films were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and contact angle test. The blood compatibility of the specimens was evaluated by tests of platelet adhesion. Results show that pure rutile phase is formed in doped samples and La(2)O(3) incorporation significantly improves the wettability and hemocompatibility of TiO(2) films. Our studies demonstrate that La(2)O(3) doped TiO(2) films are potentially useful biomaterials with good blood compatibility.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood / drug effects*
  • Blood / metabolism
  • Coated Materials, Biocompatible / chemical synthesis*
  • Coated Materials, Biocompatible / chemistry
  • Coated Materials, Biocompatible / pharmacology*
  • Efficiency / drug effects
  • Humans
  • Lanthanum / chemistry*
  • Lanthanum / pharmacology
  • Materials Testing
  • Membranes, Artificial*
  • Oxides / chemistry*
  • Oxides / pharmacology
  • Platelet Adhesiveness / drug effects
  • Platelet Count
  • Titanium / chemistry*
  • Titanium / pharmacology
  • X-Ray Diffraction

Substances

  • Coated Materials, Biocompatible
  • Membranes, Artificial
  • Oxides
  • titanium dioxide
  • lanthanum oxide
  • Lanthanum
  • Titanium