Abstract
An efficient 8-step enantioselective total synthesis of (+)-angelmarin, starting from commercially available umbelliferone, has been achieved. Key reactions include olefin cross-metathesis and a Shi epoxidation-cyclization sequence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Cyclization
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Plant Extracts / chemical synthesis*
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Plant Extracts / chemistry
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Stereoisomerism
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Umbelliferones / chemistry*
Substances
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Coumarins
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Plant Extracts
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Umbelliferones
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angelmarin
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7-hydroxycoumarin