From metal binding to nanoparticle formation: monitoring biomimetic iron oxide synthesis within protein cages using mass spectrometry

Sebyung Kang; Craig C Jolley; Lars O Liepold; Mark Young; Trevor Douglas

doi:10.1002/anie.200900437

From metal binding to nanoparticle formation: monitoring biomimetic iron oxide synthesis within protein cages using mass spectrometry

Angew Chem Int Ed Engl. 2009;48(26):4772-6. doi: 10.1002/anie.200900437.

Authors

Sebyung Kang¹, Craig C Jolley, Lars O Liepold, Mark Young, Trevor Douglas

Affiliation

¹ Department of Chemistry and Biochemistry, Center for BioInspired Nanomaterials, Montana State University, Bozeman, MT 59717, USA.

PMID: 19455534
DOI: 10.1002/anie.200900437

Abstract

Mass measurements of metal-mineralized protein cages allowed quantitative examination of the effects of metal-ion concentration on the final nanoparticle size. Modeling using a kinetic master equation suggests that particle growth involves both a binding phase and a growth phase (see picture; I: relative abundance; LiDps: a DNA binding protein; (n)Fe: number of Fe atoms).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

DNA-Binding Proteins / chemistry*
DNA-Binding Proteins / metabolism
Ferric Compounds / chemical synthesis*
Ferric Compounds / chemistry
Mass Spectrometry
Metals / chemistry*
Nanoparticles / chemistry*

Substances

DNA-Binding Proteins
Ferric Compounds
Metals
ferric oxide