A cysteine-based tripodal chelator with a high affinity and selectivity for copper(I)

J Am Chem Soc. 2009 May 27;131(20):6928-9. doi: 10.1021/ja901700a.

Abstract

A C(3)-symmetric ligand containing three converging cysteine chains anchored on a nitrilotriacetic acid moiety has been synthesized. This tripodal pseudopeptide, which provides three soft sulfur donor groups, exhibits a very high affinity for Cu(I) in either a monometallic complex or the cluster species Cu(6)L(3).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations, Monovalent / chemistry
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry*
  • Circular Dichroism
  • Copper / chemistry*
  • Cysteine / analogs & derivatives*
  • Cysteine / chemistry
  • Hydrogen-Ion Concentration
  • Ligands
  • Models, Molecular
  • Nitrilotriacetic Acid / chemical synthesis
  • Nitrilotriacetic Acid / chemistry
  • Spectrophotometry, Ultraviolet
  • Substrate Specificity

Substances

  • Cations, Monovalent
  • Chelating Agents
  • Ligands
  • Copper
  • Cysteine
  • Nitrilotriacetic Acid