Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region

Antimicrob Agents Chemother. 2009 Aug;53(8):3561-4. doi: 10.1128/AAC.00004-09. Epub 2009 May 18.

Abstract

Plasmodium vivax parasites with chloroquine resistance (CQR) are already circulating in the Brazilian Amazon. Complete single-nucleotide polymorphism (SNP) analyses of coding and noncoding sequences of the pvmdr1 and pvcrt-o genes revealed no associations with CQR, even if some mutations had not been randomly selected. In addition, striking differences in the topologies and numbers of SNPs in these transporter genes between P. vivax and P. falciparum reinforce the idea that mechanisms other than mutations may explain this virulent phenotype in P. vivax.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology
  • Brazil
  • Chloroquine / pharmacology*
  • Drug Resistance / genetics*
  • Membrane Transport Proteins / genetics*
  • Models, Biological
  • Molecular Sequence Data
  • Multidrug Resistance-Associated Proteins / genetics*
  • Plasmodium vivax / drug effects*
  • Plasmodium vivax / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Protozoan Proteins / genetics*

Substances

  • Antimalarials
  • Crt-o protein, Plasmodium vivax
  • Mdr1 protein, Plasmodium vivax
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins
  • Protozoan Proteins
  • Chloroquine

Associated data

  • GENBANK/EU333967
  • GENBANK/EU333968
  • GENBANK/EU333969
  • GENBANK/EU333970
  • GENBANK/EU333971
  • GENBANK/EU333972
  • GENBANK/EU333973
  • GENBANK/EU333974
  • GENBANK/EU333975
  • GENBANK/EU333976
  • GENBANK/EU333977
  • GENBANK/EU333978
  • GENBANK/EU333979