Abstract
Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Anti-Bacterial Agents / biosynthesis*
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Bacterial Proteins / genetics
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Drug Resistance, Bacterial*
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Erythromycin / biosynthesis
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Frameshift Mutation
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Mutant Proteins / genetics
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Mutation, Missense
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Oligomycins / biosynthesis
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Ribosomal Proteins / genetics*
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Saccharopolyspora / genetics*
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Saccharopolyspora / metabolism*
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Streptomyces / genetics*
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Streptomyces / metabolism*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Mutant Proteins
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Oligomycins
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Ribosomal Proteins
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Erythromycin