Levetiracetam-induced platelet dysfunction

Marie Hacquard; Sébastien Richard; Jean-Christophe Lacour; Thomas Lecompte; Hervé Vespignani

doi:10.1016/j.eplepsyres.2009.04.003

Levetiracetam-induced platelet dysfunction

Epilepsy Res. 2009 Sep;86(1):94-6. doi: 10.1016/j.eplepsyres.2009.04.003. Epub 2009 May 15.

Authors

Marie Hacquard¹, Sébastien Richard, Jean-Christophe Lacour, Thomas Lecompte, Hervé Vespignani

Affiliation

¹ Hématologie Biologique, CHU Nancy, allée du Morvan, Vandoeuvre-les-Nancy, France. m.toussaint-hacquard@chu-nancy.fr

PMID: 19447009
DOI: 10.1016/j.eplepsyres.2009.04.003

Abstract

Levetiracetam is an antiepileptic drug widely prescribed. We report here for the first time, an alteration of platelet function attributable to this drug. This effect has never been reported before. The responsibility of levetiracetam seems to be probable: restoration of platelet functionality was observed after withholding this treatment and this effect has been described for a structurally related molecule, piracetam.

Publication types

Case Reports

MeSH terms

Aged
Anticonvulsants / adverse effects*
Blood Platelet Disorders / chemically induced*
Blood Platelet Disorders / pathology
Clopidogrel
Humans
Levetiracetam
Magnetic Resonance Imaging / methods
Male
Piracetam / adverse effects
Piracetam / analogs & derivatives*
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / therapeutic use
Seizures / drug therapy
Ticlopidine / analogs & derivatives
Ticlopidine / therapeutic use

Substances

Anticonvulsants
Platelet Aggregation Inhibitors
Levetiracetam
Clopidogrel
Ticlopidine
Piracetam