Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries

Chembiochem. 2009 Jun 15;10(9):1490-4. doi: 10.1002/cbic.200900220.

Abstract

Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • HIV Long Terminal Repeat*
  • Ligands*
  • Nucleic Acid Conformation
  • Peptides / chemistry
  • RNA, Viral / chemistry*

Substances

  • Ligands
  • Peptides
  • RNA, Viral