LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8941-6. doi: 10.1073/pnas.0812469106. Epub 2009 May 14.

Abstract

The serine-threonine kinase LKB1 regulates cell polarity from Caenorhabditis elegans to man. Loss of lkb1 leads to a cancer predisposition, known as Peutz-Jeghers Syndrome. Biochemical analysis indicates that LKB1 can phosphorylate and activate a family of AMPK- like kinases, however, the precise contribution of these kinases to the establishment and maintenance of cell polarity is still unclear. Recent studies propose that LKB1 acts primarily through the AMP kinase to establish and/or maintain cell polarity. To determine whether this simple model of how LKB1 regulates cell polarity has relevance to complex tissues, we examined lkb1 mutants in the Drosophila eye. We show that adherens junctions expand and apical, junctional, and basolateral domains mix in lkb1 mutants. Surprisingly, we find LKB1 does not act primarily through AMPK to regulate cell polarity in the retina. Unlike lkb1 mutants, ampk retinas do not show elongated rhabdomeres or expansion of apical and junctional markers into the basolateral domain. In addition, nutrient deprivation does not reveal a more dramatic polarity phenotype in lkb1 photoreceptors. These data suggest that AMPK is not the primary target of LKB1 during eye development. Instead, we find that a number of other AMPK-like kinase, such as SIK, NUAK, Par-1, KP78a, and KP78b show phenotypes similar to weak lkb1 loss of function in the eye. These data suggest that in complex tissues, LKB1 acts on an array of targets to regulate cell polarity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinase Kinases
  • AMP-Activated Protein Kinases / metabolism
  • Adherens Junctions / genetics
  • Adherens Junctions / metabolism*
  • Animals
  • Cell Polarity* / genetics
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / enzymology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / growth & development*
  • Eye / growth & development*
  • Eye / ultrastructure
  • Mutation
  • Photoreceptor Cells, Invertebrate / enzymology
  • Photoreceptor Cells, Invertebrate / ultrastructure
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Pupa / enzymology
  • Pupa / genetics
  • Pupa / growth & development
  • Retina / growth & development
  • Retina / ultrastructure

Substances

  • Drosophila Proteins
  • Protein Kinases
  • AMPKalpha protein, Drosophila
  • LKB1 protein, Drosophila
  • AMP-Activated Protein Kinase Kinases
  • AMP-Activated Protein Kinases