Intercellular lipid mediators such as prostaglandins and lysophosphatidic acid (LPA) interact with their G-protein-coupled receptors (GPCR) in the plasma membrane to modulate functions of target cells or tissues. Discovery of new members of intercellular lipid mediators and their GPCRs have been milestones in lipid biology and the foundation for drug development. Recent advances in intercellular lipid mediators are very interesting. New lipid molecules have been recognized as intercellular signaling mediators acting on GPCRs including resolvin E1, eoxin, acylethanolamides (arachidnonylethanolamide and oleoylethanolamide), fatty acids, bile acids, lipoamino aicd (N-palmitoyl glycine and N-arachidonyl glycine), estrogen, 5-oxo-ETE and 9-hydroxyoctadecadienoic acid, among others. Also new GPCRs for LPA have been identified. New intercellular lipid mediators and their GPCRs are reviewed.