In the past years, laser ablation synthesis in solution (LASiS) emerged as a reliable alternative to traditional chemical reduction methods for obtaining noble metal nanoparticles (NMNp). LASiS is a "green" technique for the synthesis of stable NMNp in water or in organic solvents, which does not need stabilizing molecules or other chemicals. The so obtained NMNp are highly available for further functionalization or can be used wherever unprotected metal nanoparticles are desired. Surface functionalization of NMNp can be monitored in real time by UV-visible spectroscopy of the plasmon resonance. However LASiS has some limitations in the size control of NMNp, which can be overcome by "chemical free" laser treatments of NMNp. In this paper we provide an overview of LASiS, size manipulation by laser irradiation and functionalization of NMNp, with special care in pointing out some of the main issues about this research area.