Background: Edema associated with quetiapine has been described in only one case report to date and represents a potentially serious adverse reaction.
Methods: We present a case series of 3 patients who developed bilateral leg edema following initiation of quetiapine.
Results: One of these patients had a recurrence of edema with subsequent rechallenge. Another patient developed quetiapine-induced edema following a prior episode of olanzapine-induced edema. All 3 cases present a compelling temporal relationship between the drug challenge and the adverse event.
Conclusion: Prompt recognition and intervention with discontinuation of the offending agent is important for this potentially serious, seemingly idiosyncratic vascular complication.