Changes in the marginal and internal fit during manufacture are detrimental to the long-term success of fixed dental prostheses (FDPs). Hence, the aim of this study was to investigate the distortion of four-unit zirconia bridges induced by the veneering process with in vitro and finite element analyses (FEA). Ten all-ceramic FDPs with zirconia frameworks were prepared. The marginal and internal fit of the restorations were determined prior to and after veneering by means of a replica technique. Additionally, a three-dimensional finite element model of the restoration was constructed and cooling after the veneering process was virtually simulated. Statistical analysis revealed significant changes in the marginal and internal fit due to the veneering process. FEA verified these observations and displayed tensile stresses (up to 65MPa) within the framework and compressive stresses (up to 10MPa) within the veneering layer. The present study showed that stresses and distortions, occurring due to the veneering process, may influence the marginal and internal fit and therefore the clinical success of dental restorations.