Molecular rods with oligospiroketal backbones as anchors in biological membranes

Angew Chem Int Ed Engl. 2009;48(24):4433-5. doi: 10.1002/anie.200901133.

Abstract

Getting stuck in: A hydrophobic molecular rod with terminal fluorescent moieties has been synthesized. The insertion of the rod into membranes was investigated and shown to incorporate efficiently into model and biological membranes (see picture; gray C, blue N, red O). Those rods can be used as stable membrane-associated anchors for functionalization of membrane surfaces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cell Membrane / chemistry*
  • Fluorescent Dyes / chemistry
  • Furans / chemical synthesis
  • Furans / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Peptides / chemistry*
  • Spectrometry, Fluorescence
  • Spiro Compounds / chemical synthesis
  • Spiro Compounds / chemistry*

Substances

  • Fluorescent Dyes
  • Furans
  • Peptides
  • Spiro Compounds
  • spiroketal