Synthesis and biological evaluation of c7-demethyl largazole analogues

ChemMedChem. 2009 Aug;4(8):1269-72. doi: 10.1002/cmdc.200900125.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Binding Sites
  • Cell Line, Tumor
  • Computer Simulation
  • Depsipeptides / chemical synthesis
  • Depsipeptides / chemistry*
  • Depsipeptides / pharmacology
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases / metabolism
  • Humans
  • Recombinant Proteins / antagonists & inhibitors
  • Recombinant Proteins / metabolism
  • Structure-Activity Relationship
  • Thiazoles / chemical synthesis
  • Thiazoles / chemistry*
  • Thiazoles / pharmacology

Substances

  • Antineoplastic Agents
  • Depsipeptides
  • Histone Deacetylase Inhibitors
  • Recombinant Proteins
  • Thiazoles
  • largazole
  • Histone Deacetylases