Molecular properties, functions, and potential applications of NAD kinases

Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):352-61. doi: 10.1093/abbs/gmp029.

Abstract

NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP(+)/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H) conversion. Here, the molecular properties, physiologic functions, and potential applications of NAD kinase are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Models, Biological
  • Molecular Sequence Data
  • Molecular Structure
  • NAD / chemistry
  • NAD / metabolism*
  • NADP / chemistry
  • NADP / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Sequence Homology, Amino Acid

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • NAD
  • NADP
  • Phosphotransferases (Alcohol Group Acceptor)
  • NAD kinase