Abstract
NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP(+)/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H) conversion. Here, the molecular properties, physiologic functions, and potential applications of NAD kinase are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Models, Biological
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Molecular Sequence Data
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Molecular Structure
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NAD / chemistry
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NAD / metabolism*
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NADP / chemistry
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NADP / metabolism*
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Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
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Phosphotransferases (Alcohol Group Acceptor) / genetics
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Sequence Homology, Amino Acid
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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NAD
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NADP
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Phosphotransferases (Alcohol Group Acceptor)
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NAD kinase