A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome. Spinal fluid analysis showed a normal protein level, vindesine neuropathy seemed to be the cause of the patient's neurological symptoms. The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.