A generalized kinetic model resulting from several modifications of the one originally known as the Series Event Model has been applied to describe three different disinfection processes and compare their efficiencies. The work was performed in a well-defined, versatile batch reactor employing Escherichia coli as a subrogate bacteria. The following systems were studied: (i) UVC radiation alone, (ii) hydrogen peroxide alone and (iii) UVC radiation combined with hydrogen peroxide. The kinetic parameters of the three models were determined. Within the range of studied operating conditions, the use of UVC alone has shown to produce the best results.