The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea

D B da Silva; E C O Tulli; G C G Militão; L V Costa-Lotufo; C Pessoa; M O de Moraes; S Albuquerque; J M de Siqueira

doi:10.1016/j.phymed.2009.03.019

The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea

Phytomedicine. 2009 Nov;16(11):1059-63. doi: 10.1016/j.phymed.2009.03.019. Epub 2009 May 7.

Authors

D B da Silva¹, E C O Tulli, G C G Militão, L V Costa-Lotufo, C Pessoa, M O de Moraes, S Albuquerque, J M de Siqueira

Affiliation

¹ Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, Brazil. debrentan@fcfrp.usp.br

PMID: 19423311
DOI: 10.1016/j.phymed.2009.03.019

Abstract

The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC(50) 0.01 microM). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 microM) than other alkaloids tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / isolation & purification
Alkaloids / pharmacology*
Annonaceae / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification*
Aporphines / isolation & purification
Aporphines / pharmacology
Cell Line, Tumor
Humans
Leishmania braziliensis / drug effects*
Molecular Structure
Plant Extracts / pharmacology
Trypanocidal Agents / isolation & purification*
Trypanosoma cruzi / drug effects

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Aporphines
Plant Extracts
Trypanocidal Agents
duguetine
duguetine beta-N-oxide
dicentrinone