Prenylflavonols from the leaves of Macaranga sampsonii

Chem Pharm Bull (Tokyo). 2009 May;57(5):495-8. doi: 10.1248/cpb.57.495.

Abstract

Four novel prenylflavonols, macaranones A-D (1-4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavonols having an unusual peltogynoid skeleton which is formed from a 2'-geranylflavonol by cyclization between 3-OH and C-1'' of the 2'-geranyl substituent of the flavonol. Compounds 1-4 were evaluated for the cytotoxicity against several human cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Euphorbiaceae / chemistry*
  • Flavonoids / chemistry*
  • Flavonoids / toxicity
  • Flavonols / chemistry*
  • Flavonols / therapeutic use
  • Humans
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / toxicity
  • Plant Leaves / chemistry*
  • Prenylation

Substances

  • Antineoplastic Agents
  • Flavonoids
  • Flavonols
  • Plant Extracts
  • macaranone A
  • macaranone B
  • macaranone C
  • macaranone D