Abstract
Four novel prenylflavonols, macaranones A-D (1-4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavonols having an unusual peltogynoid skeleton which is formed from a 2'-geranylflavonol by cyclization between 3-OH and C-1'' of the 2'-geranyl substituent of the flavonol. Compounds 1-4 were evaluated for the cytotoxicity against several human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity
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Cell Line, Tumor
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Euphorbiaceae / chemistry*
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Flavonoids / chemistry*
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Flavonoids / toxicity
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Flavonols / chemistry*
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Flavonols / therapeutic use
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Humans
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / toxicity
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Plant Leaves / chemistry*
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Prenylation
Substances
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Antineoplastic Agents
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Flavonoids
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Flavonols
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Plant Extracts
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macaranone A
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macaranone B
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macaranone C
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macaranone D