Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro

Chembiochem. 2009 May 25;10(8):1325-9. doi: 10.1002/cbic.200900044.

Abstract

See you later amyloid beta: A screen of a small library of oxime oligomers with an HTS fluorescence assay for amyloid fibril inhibition and subsequent investigation by atomic force microscopy revealed two new micromolar inhibitors of amyloid fibril formation. These new inhibitors have IC(50) values in the 10 microM range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism
  • Amyloid / antagonists & inhibitors
  • Amyloid / drug effects*
  • Amyloid / ultrastructure
  • Amyloid beta-Peptides / drug effects*
  • Humans
  • Microscopy, Atomic Force
  • Oximes / chemistry*
  • Oximes / pharmacology
  • Peptides / drug effects
  • Small Molecule Libraries
  • Spectrometry, Fluorescence

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Oximes
  • Peptides
  • Small Molecule Libraries