Inflamed snail speeds metastasis

Cancer Cell. 2009 May 5;15(5):355-7. doi: 10.1016/j.ccr.2009.04.003.

Abstract

Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFalpha-dependent NFkappaB activation induces COP9 signalosome-mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • COP9 Signalosome Complex
  • Cell Movement / physiology
  • Cell Transformation, Neoplastic / metabolism*
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors
  • Glycogen Synthase Kinase 3 beta
  • Humans
  • Inflammation / metabolism
  • Macrophages / metabolism
  • Macrophages / pathology
  • Multiprotein Complexes / metabolism
  • NF-kappa B / metabolism
  • Neoplasm Metastasis*
  • Peptide Hydrolases / metabolism
  • SKP Cullin F-Box Protein Ligases / antagonists & inhibitors
  • Signal Transduction
  • Snail Family Transcription Factors
  • Transcription Factors / metabolism
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Multiprotein Complexes
  • NF-kappa B
  • Snail Family Transcription Factors
  • Transcription Factors
  • Tumor Necrosis Factor-alpha
  • SKP Cullin F-Box Protein Ligases
  • GSK3B protein, human
  • Glycogen Synthase Kinase 3 beta
  • Glycogen Synthase Kinase 3
  • Peptide Hydrolases
  • COP9 Signalosome Complex