Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes

J Dermatol Sci. 2009 Aug;55(2):134-6. doi: 10.1016/j.jdermsci.2009.04.001. Epub 2009 May 5.
No abstract available

Publication types

  • Letter

MeSH terms

  • Active Transport, Cell Nucleus
  • Casein Kinase II / antagonists & inhibitors*
  • Casein Kinase II / metabolism
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism*
  • DNA Replication / drug effects*
  • Dose-Response Relationship, Drug
  • Down-Regulation
  • E2F1 Transcription Factor / metabolism*
  • Epidermis / drug effects*
  • Epidermis / enzymology
  • Humans
  • Keratinocytes / drug effects*
  • Keratinocytes / enzymology
  • Protein Kinase Inhibitors / pharmacology*
  • Proto-Oncogene Proteins c-myc / metabolism
  • Signal Transduction / drug effects
  • Triazoles / pharmacology*

Substances

  • 4,5,6,7-tetrabromobenzotriazole
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • E2F1 Transcription Factor
  • E2F1 protein, human
  • MYC protein, human
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-myc
  • Triazoles
  • Casein Kinase II