Preparation, characterization, and antitumor activity of water-soluble aminoalkanol platinum(II) complexes

J Inorg Biochem. 1991 Jul;43(1):57-63. doi: 10.1016/0162-0134(91)84070-p.

Abstract

A new series of highly water-soluble aminoalkanol platinum(II) complexes have been synthesized and characterized by elemental analysis, conductance, IR, and 195Pt NMR. Preliminary in vitro and in vivo screening tests for antitumor activities of these complexes against L1210 murine leukemia were performed. In general, these compounds were far less cytotoxic than cisplatin and possessed only a moderate degree of antitumor activity.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents*
  • Cisplatin / pharmacology
  • Cisplatin / toxicity
  • Drug Evaluation, Preclinical
  • Lethal Dose 50
  • Leukemia L1210 / drug therapy
  • Magnetic Resonance Spectroscopy
  • Mice
  • Organoplatinum Compounds / chemistry
  • Organoplatinum Compounds / pharmacology*
  • Organoplatinum Compounds / toxicity
  • Solubility
  • Water

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Water
  • Cisplatin