Light-induced temperature transitions in biodegradable polymer and nanorod composites

Small. 2009 Aug 17;5(16):1830-4. doi: 10.1002/smll.200900395.

Abstract

Shape-memory materials (including polymers, metals, and ceramics) are those that are processed into a temporary shape and respond to some external stimuli (e.g., temperature) to undergo a transition back to a permanent shape.[1, 2] Shape memory polymers are finding use in a range of applications from aerospace to fabrics, to biomedical devices and microsystem components.[–5] For many applications, it would be beneficial to initiate heating with an external trigger (e.g., transdermal light exposure). In this work, we formulated composites of gold nanorods (<1% by volume) and biodegradable networks, where exposure to infrared light induced heating and consequently, shape transitions. The heating is repeatable and tunable based on nanorod concentration and light intensity and the nanorods did not alter the cytotoxicity or in vivo tissue response to the networks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biodegradation, Environmental*
  • Cell Survival
  • Equipment Design
  • Light
  • Male
  • Metals / chemistry
  • Nanocomposites / chemistry*
  • Nanotubes / chemistry*
  • Polymers / chemistry*
  • Prostheses and Implants
  • Rats
  • Rats, Sprague-Dawley
  • Temperature

Substances

  • Biocompatible Materials
  • Metals
  • Polymers