Three new triterpenoid saponins from the leaves and stems of Panax quinquefolium

J Asian Nat Prod Res. 2009;11(3):195-201. doi: 10.1080/10286020802682734.

Abstract

Three new minor dammarane saponins, quinquenosides L10 (1), L14 (2), and L16 (3), were isolated from the leaves and stems of Panax quinquefolium L. By the combination of one- and two-dimensional NMR techniques and MS spectroscopic analysis, their structures were established as 20-O-(alpha-L-arabinopyranosyl-(1-6)-O-beta-D-glucopyranosyl)-3-O-beta-D-glucopyranosyl-dammar-24-ene-3,12, 20-triol (1), 20-O-alpha-L-arabinopyranosyl-3-O-(beta-D-glucopyranosyl-(1-2)-O-beta-d-glucopyranosyl)-dammar-24-ene-3,12,20-triol (2), 3-O-(beta-D-glucopyranosyl-(1-2)-O-beta-d-glucopyranosyl)-20-O-(beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl)-dammarane-3,12,20,24,25-pentaol (3). The content of artemisinin was significantly enhanced by 3.0 mg l(- 1) of compounds 1, 2, and 3 in the callus of Artemisia annua.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dammaranes
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Ginsenosides / chemistry
  • Ginsenosides / isolation & purification*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Panax / chemistry*
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification*

Substances

  • Drugs, Chinese Herbal
  • Ginsenosides
  • Triterpenes
  • quinquenoside L10
  • quinquenoside L14
  • quinquenoside L16