Medicine. Avoiding unintended toxicity

Science. 2009 May 1;324(5927):603-4. doi: 10.1126/science.1174267.
No abstract available

Publication types

  • Comment

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid Precursor Protein Secretases / chemistry
  • Amyloid Precursor Protein Secretases / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Endopeptidases / chemistry
  • Endopeptidases / metabolism*
  • Humans
  • Membrane Proteins
  • Mice
  • Protease Inhibitors / pharmacology*
  • Protease Inhibitors / therapeutic use
  • Protease Inhibitors / toxicity
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism
  • Receptors, Notch / antagonists & inhibitors
  • Receptors, Notch / metabolism
  • Signal Transduction / drug effects

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • Protease Inhibitors
  • Protein Subunits
  • Receptors, Notch
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aph1C protein, mouse
  • Aph1a protein, mouse
  • Aph1b protein, mouse