Reliability of the Vitek 2 yeast susceptibility test for detection of in vitro resistance to fluconazole and voriconazole in clinical isolates of Candida albicans and Candida glabrata

J Clin Microbiol. 2009 Jun;47(6):1927-30. doi: 10.1128/JCM.02070-08. Epub 2009 Apr 29.

Abstract

The Vitek 2 yeast susceptibility test was evaluated by testing 122 Candida isolates against fluconazole and voriconazole. Excellent categorical agreement with the CLSI broth microdilution method was observed (97.5% for both the azoles). Moreover, the Vitek 2 system was able to identify all but 2 of 59 investigated fluconazole-resistant organisms.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Candida albicans / isolation & purification
  • Candida glabrata / drug effects*
  • Candida glabrata / isolation & purification
  • Candidiasis / microbiology
  • Drug Resistance, Fungal
  • Fluconazole / pharmacology*
  • Humans
  • Microbial Sensitivity Tests / methods
  • Pyrimidines / pharmacology*
  • Sensitivity and Specificity
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Fluconazole
  • Voriconazole