Metal-Brønsted acid cooperative catalysis for asymmetric reductive amination

Chaoqun Li; Barbara Villa-Marcos; Jianliang Xiao

doi:10.1021/ja9021683

Metal-Brønsted acid cooperative catalysis for asymmetric reductive amination

J Am Chem Soc. 2009 May 27;131(20):6967-9. doi: 10.1021/ja9021683.

Authors

Chaoqun Li¹, Barbara Villa-Marcos, Jianliang Xiao

Affiliation

¹ Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK.

PMID: 19402701
DOI: 10.1021/ja9021683

Abstract

Direct reductive amination of a wide range of ketones has been accomplished by the cooperative catalysis of an Ir(III)-diamine complex and a chiral phosphoric acid or its conjugate base.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Amines / chemical synthesis*
Aniline Compounds / chemical synthesis
Aniline Compounds / chemistry
Catalysis
Iridium / chemistry
Ketones / chemistry*
Organometallic Compounds / chemistry

Substances

Amines
Aniline Compounds
Ketones
Organometallic Compounds
Iridium