WHO fracture risk calculator (FRAX) in the assessment of obese patients with osteoporosis

Endokrynol Pol. 2009 Mar-Apr;60(2):82-7.

Abstract

Introduction: Recently, a new fracture risk-assessment calculator (FRAX) has been introduced. The aim of this study was to assess its usefulness for the re-assessment of fracture risk in obese patients and re-assignment to treatment.

Material and methods: 350 obese female patients were included. In all of them, 10-year fracture risk was calculated using FRAX (with and without T score value).

Results: If major osteoporotic fracture risk was calculated with BMD, it was low in most of the patients (in 82.1% of those treated, and in 95.9% of those not treated it was below 10%). Mean risk values were significantly higher in the treated (7.7 [3;39]%) than in the non-treated group (4.6 [2.1;14]%). The reason for start of treatment in 95 out of 106 patients was a sustained low-energy fracture, low BMD, or both.

Conclusions: The WHO fracture risk calculator may be a useful tool in treated obese females with osteoporosis. The information regarding 10-year fracture risk may change the treatment strategy at least for those in whom the decision of treatment was based solely on low BMD.

MeSH terms

  • Aged
  • Bone Density
  • Bone Density Conservation Agents / administration & dosage
  • Calcium / administration & dosage
  • Clodronic Acid / administration & dosage
  • Comorbidity
  • Female
  • Fractures, Bone / epidemiology*
  • Humans
  • Obesity / epidemiology*
  • Osteoporosis / epidemiology*
  • Osteoporosis / prevention & control
  • Poland / epidemiology
  • Risk Assessment / methods*
  • Vitamin D / administration & dosage
  • World Health Organization

Substances

  • Bone Density Conservation Agents
  • Clodronic Acid
  • Vitamin D
  • Calcium