Protective effects of celery juice in treatments with Doxorubicin

Molecules. 2009 Apr 24;14(4):1627-38. doi: 10.3390/molecules14041627.

Abstract

The aim of this work was to investigate possible protective effect of celery juice in doxorubicin treatment. The following biochemical parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity in liver homogenate and blood hemolysate. We examined influence of diluted pure celery leaves and roots juices and their combinations with doxorubicine on analyzed biochemical parameters. Celery roots and leaves juices influenced the examined biochemical parameters and showed protective effects when applied with doxorubicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Apium / anatomy & histology
  • Apium / chemistry*
  • Blood Proteins / metabolism
  • Catalase / metabolism
  • Cytoprotection*
  • Doxorubicin* / pharmacology
  • Doxorubicin* / toxicity
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxidation
  • Liver / drug effects*
  • Liver / enzymology
  • Mice
  • Peroxidase / metabolism
  • Plant Extracts* / chemistry
  • Plant Extracts* / pharmacology
  • Plants, Medicinal / chemistry
  • Xanthine Oxidase / metabolism

Substances

  • Antioxidants
  • Blood Proteins
  • Plant Extracts
  • Doxorubicin
  • Catalase
  • Peroxidase
  • Glutathione Peroxidase
  • Xanthine Oxidase
  • Glutathione