Systems biology makes it personal

Mark P Brynildsen; James J Collins

doi:10.1016/j.molcel.2009.04.004

Systems biology makes it personal

Mol Cell. 2009 Apr 24;34(2):137-8. doi: 10.1016/j.molcel.2009.04.004.

Authors

Mark P Brynildsen¹, James J Collins

Affiliation

¹ Howard Hughes Medical Institute, Biomedical Engineering Department, Center for BioDynamics and Center for Applied Biotechnology, Boston University, 44 Cummington Street, Boston, MA 02215, USA.

PMID: 19394290
DOI: 10.1016/j.molcel.2009.04.004

Abstract

Systems biology promises to personalize medicine via network-based biomarkers that predict therapeutic effectiveness. Toward this goal, Chang et al. (2009) recently introduced a systems-based approach to break down oncogenic signaling networks into modules that predict the effectiveness of pathway-specific therapeutics.

Publication types

Comment

MeSH terms

Antineoplastic Agents / therapeutic use*
Biomarkers, Pharmacological / analysis*
Cell Line, Tumor
Gene Expression Regulation, Neoplastic*
Humans
Neoplasms / drug therapy
Neoplasms / genetics*
Signal Transduction*
Systems Biology
Treatment Outcome

Substances

Antineoplastic Agents
Biomarkers, Pharmacological