Monte Carlo modelling of the influence of boron microdistribution on BNCT microdosimetry

Richard P Hugtenburg; Adam E R Baker; Stuart Green

doi:10.1016/j.apradiso.2009.03.041

Monte Carlo modelling of the influence of boron microdistribution on BNCT microdosimetry

Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S168-70. doi: 10.1016/j.apradiso.2009.03.041. Epub 2009 Mar 27.

Authors

Richard P Hugtenburg¹, Adam E R Baker, Stuart Green

Affiliation

¹ School of Medicine, Swansea University, UK. r.p.hugtenburg@swansea.ac.uk

PMID: 19394241
DOI: 10.1016/j.apradiso.2009.03.041

Abstract

The ion transport Monte Carlo code SRIM has been used to calculate single event lineal energy spectra for the products of the boron-neutron capture reaction in a water-based medium. The event spectra have been benchmarked against spectra measured with a boron-loaded tissue-equivalent proportional counter (TEPC). Agreement is excellent and supports the use of Monte Carlo methods in understanding the influence of boron delivery on the effectiveness of boron-neutron capture therapy (BNCT).

MeSH terms

Boron / pharmacokinetics*
Boron / therapeutic use*
Boron Neutron Capture Therapy / statistics & numerical data*
Helium / radiation effects
Humans
Linear Energy Transfer
Lithium / radiation effects
Monte Carlo Method
Neoplasms / metabolism
Neoplasms / radiotherapy
Phantoms, Imaging
Radiation-Sensitizing Agents / pharmacokinetics*
Radiation-Sensitizing Agents / therapeutic use*
Radiotherapy Planning, Computer-Assisted / statistics & numerical data*

Substances

Radiation-Sensitizing Agents
Helium
Lithium
Boron