CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration

Qingxiao Zhao; Qun Wei; Aimin He; Ruokun Jia; Yongtao Xiao

doi:10.1016/j.bbrc.2009.04.088

CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration

Biochem Biophys Res Commun. 2009 Jul 3;384(3):277-9. doi: 10.1016/j.bbrc.2009.04.088. Epub 2009 Apr 23.

Authors

Qingxiao Zhao¹, Qun Wei, Aimin He, Ruokun Jia, Yongtao Xiao

Affiliation

¹ College of Chemical Engineering, Northeast Dianli University, Jilin, PR China. Xiaozhaoqingxiao@163.com

PMID: 19393632
DOI: 10.1016/j.bbrc.2009.04.088

Abstract

CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.

Publication types

Review

MeSH terms

Animals
Chloride Channels / antagonists & inhibitors*
Chloride Channels / genetics
Chloride Channels / metabolism*
Humans
Mice
Neurodegenerative Diseases / drug therapy*
Neurodegenerative Diseases / genetics
Neurodegenerative Diseases / metabolism
Osteopetrosis / drug therapy*
Osteopetrosis / genetics
Osteopetrosis / metabolism
Retinal Degeneration / drug therapy*
Retinal Degeneration / genetics
Retinal Degeneration / metabolism

Substances

CLCN7 protein, human
Chloride Channels